Hormonal control of aging in rodents: The somatotropic axis
نویسندگان
چکیده
منابع مشابه
Nucleotide excision repair deficiencies and the somatotropic axis in aging.
The physicochemical constitution of DNA cannot warrant lifelong stability. Yet, unlike all other macromolecules, nuclear DNA must last the lifetime of a cell ensuring that its vital genetic information is preserved and faithfully transmitted to progeny. An increasing body of evidence suggests that progressive genome instability likely contributes to aging and shortens lifespan. In support, defe...
متن کاملThe somatotropic axis and longevity in mice.
The somatotropic signaling pathway has been implicated in aging and longevity studies in mice and other species. The physiology and lifespans of a variety of mutant mice, both spontaneous and genetically engineered, have contributed to our current understanding of the role of growth hormone and insulin-like growth factor I on aging-related processes. Several other mice discovered to live longer...
متن کاملAging and hormones of the hypothalamo-pituitary axis: gonadotropic axis in men and somatotropic axes in men and women.
Neuroendocrinology of the aging (male) gonadal and (male and female) somatotropic axes will be reviewed. A companion chapter discusses reproductive hormonal changes in aging women. Both the gonadal and growth-hormone/insulin-like growth factor (GH/IGF-I) axes function as ensembles. The ensembles comprise tripartite interactions among the brain (hypothalamus), anterior pituitary gland (gonadotro...
متن کاملThe Role of the Somatotropic Axis in the Mamalian Metabolism
The metabolism in mammalian is regulated by multiple levels of hormone action, with complex feedback and control mechanisms. The somatotropic axis, primarily consisting of growth hormone, insulin-like growth factors (-I and –II), their associated carrier proteins (GHBP and IGFBPs), and receptors, plays a key role in the control of the regulation of metabolism and physiological process. Among th...
متن کاملMilk consumption and the prepubertal somatotropic axis
BACKGROUND Nutrients, hormones and growth factors in dairy foods may stimulate growth hormone (GH), insulin-like growth factor I (IGF-I), and raise the ratio of IGF-I to its binding protein, IGFBP-3. We conducted pilot studies in Mongolia and Massachusetts to test the extent to which milk intake raised somatotropic hormone concentrations in prepubertal children. METHODS In Ulaanbaatar, we com...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2009
ISSN: 0303-7207
DOI: 10.1016/j.mce.2008.07.001